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Re: D-amphetamine = Serotonin? SLS

Posted by psychobot5000 on May 14, 2012, at 18:09:56

In reply to D-amphetamine (Dexedrine; Adderal) = Serotonin? linkadge, posted by SLS on May 2, 2012, at 7:05:49

Scott, I found these numbers for binding affinity of d-amphetamine in the wikipedia article on neurotransmitter releasing agents:

(d)-Amphetamine NA: 7.07 DA: 24.8 SE: 1,765

Since l-amphetamine does not much affect the DA transporter, wikipedia was willing to state unequivocally that that molecule is selective for the NA transporter.

In general, you need a substantial effect on serotonin, above and beyond that provided by a powerful MAOi, to cause serotonin syndrome. I very much doubt amphetamine has an effect of that size; in any case, in patients of the level of treatment resistance likely to be present when MAOis are combined with stimulants, the risk is almost certainly worth it.

-P

> Hi Linkadge.
>
> All in all, most of the literature I found states that amphetamine releases serotonin. You were right (as usual).
>
> I found some referenced literature on Wiki indicating serotonin release is a property of d-amphetamine. Unfortunately, the conclusions reached in these investigations rely upon inferences based on indirect in vivo observations using pharmacological probes rather than direct in vitro measurements using synaptosomes.
>
> The following study is interesting:
>
> http://www.ncbi.nlm.nih.gov/pubmed/21615721
>
> It reported actual measurements of serotonin concentrations in response to different drugs. Amphetamine was the weakest at increasing extracellular serotonin. This is not an insignificant finding. However, again, it is an in vivo measurement. It is possible that this measurement represents an indirect increase of serotonin activity resulting from negative feedback loops that are wired to attenuate hyperlocomotion
>
> http://www.ncbi.nlm.nih.gov/pubmed/15545015
>
> Obviously, I am cherry-picking.
>
>
> - Scott
>


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