Posted by ed_uk2010 on February 27, 2012, at 1:41:04
In reply to Re: med strongest on serotonin, posted by linkadge on February 26, 2012, at 19:54:38
> The degree of serotonin reuptake inhibition is also a function of the dose. Paxil may have the highest affinity for the serotonin transporter (on a mg / mg basis), but some of the SSRIs (i.e. zoloft) are dosed higher.
The dose is one factor, but the various SSRIs have different pharmacokinetics eg. absorption and distribution into tissues. Drug concentrations in the brain therefore differ.
Looking at Ki data is isolation is very misleading. As a non-SSRI example, the high Ki's of Seroquel might lead you to believe that it would not be an effective antipsychotic, but the dose and drug concentrations in the brain are high (making it active), and if you compare the Ki's for different receptors you see the expected pattern - more potent at 5-HT2 than D2.
poster:ed_uk2010
thread:1011540
URL: http://www.dr-bob.org/babble/20120221/msgs/1011720.html