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Re: med strongest on serotonin » SLS

Posted by ed_uk2010 on February 27, 2012, at 1:32:14

In reply to Re: med strongest on serotonin » Laney, posted by SLS on February 26, 2012, at 12:55:35

>Effexor is not nearly as potent as Paxil or Cymbalta at the serotonin transporter.

In terms of affinity, yes, but Effexor is presumably a potent SRI clinically because the concentration of drug reached at the site of action is very high. Affinity is only one part of the equation, drug concentration at the active site being the other major player.

>I had thought that perhaps having a short half-life was contributory to a drug having a more severe withdrawal syndrome.

It's certainly a very major factor.

>you would think that clomipramine (Anafranil) would be just as bad as Paxil.

Although I suspect that if Anafranil was as widely used as Paxil and Effexor we would hear a lot more complaints about Anafranil withdrawal!

 

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