Posted by Chairman_MAO on October 21, 2011, at 18:22:37
In reply to Re: opiates and major depression » Chairman_MAO, posted by europerep on October 20, 2011, at 15:30:27
> My point was simply this: pharmacology matters.
>
> It matters when explaining to a doctor why giving buprenorphine to a patient with TRD is not like prescribing morphine, or for that matter, heroin.It matters more to drug-warriors and their sycophants, as well as physicians, because they have to live in fear of having their careers destroyed for prescribing opioids. It is very much like prescribing morphine or heroin. It is a different drug with a different receptor binding profile, but the only thing that matters is how someone feels. If buprenorphine works better, great. If heroin or methadone works better, great.
>It matters when trying to point out why the risk-benefit ratio with buprenorphine is better than with oxycodone or hydromorphone. And lastly, it matters when looking at what future drug treatments could or should look like.
Risk to who? Overdose is difficult; TCAs are more dangerous.
>
> That's all I wanted to say.I don't mean to sound snarky, but drugs are drugs, the statist apparatus notwithstanding.
poster:Chairman_MAO
thread:81414
URL: http://www.dr-bob.org/babble/20111016/msgs/1000436.html