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Re: opiates and major depression Chairman_MAO

Posted by europerep on October 19, 2011, at 8:32:45

In reply to Re: opiates and major depression CaptainAmerica1967, posted by Chairman_MAO on October 18, 2011, at 20:33:47

> You found success with it because it is a mu-opioid agonist. You'd have just as much success with morphine. The kappa antagonist effect is good, but let's keep it real here.

Actually, buprenorphine is a partial mu-opioid agonist. Furthermore, research on kappa-antagonism shows its potential for treating depression, so this component of buprenorphine may well play a role. Lastly, buprenorphine's metabolite norbuprenorphine is a delta-agonist, which may as well contribute to buprenorphine's antidepressant potential.




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