Posted by europerep on October 19, 2011, at 8:32:45
In reply to Re: opiates and major depression » CaptainAmerica1967, posted by Chairman_MAO on October 18, 2011, at 20:33:47
> You found success with it because it is a mu-opioid agonist. You'd have just as much success with morphine. The kappa antagonist effect is good, but let's keep it real here.
Actually, buprenorphine is a partial mu-opioid agonist. Furthermore, research on kappa-antagonism shows its potential for treating depression, so this component of buprenorphine may well play a role. Lastly, buprenorphine's metabolite norbuprenorphine is a delta-agonist, which may as well contribute to buprenorphine's antidepressant potential.