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Re: Mirtazapine and blood sugar

Posted by sk85 on May 3, 2011, at 15:23:07

In reply to Re: Mirtazapine and blood sugar, posted by desolationrower on May 2, 2011, at 4:04:39

>The claim that 5-ht2c strongly impacts appetite seems dubious because the effects it would predict, such as SSRIs causing weight-loss, have not proved true.

SSRIs initally do lower food intake (5-HT2C agonism) but over long-term they desensitize and downregulate the receptor (i.e there are fewer functional receptors and the few still there are less responsive) and so the opposite effect starts to dominate and hunger ensues.

I constantly monitor my glucose and I'm taking Remeron at the moment and I have not noticed it to effect my glucose in any direction.

-Ikaros


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URL: http://www.dr-bob.org/babble/20110502/msgs/984451.html