Posted by desolationrower on May 1, 2011, at 16:21:05
In reply to Re: Mirtazapine and blood sugar » desolationrower, posted by mtdewcmu on April 30, 2011, at 19:12:11
> > Yohimbine doesn't have those two effects (and has some other ones instead) but it is useful for weight loss.
> That is a good point that yohimbine doesn't cause weight gain. But maybe yohimbine's effects at other receptors cancels out this effect.
no i think the mechanistic evidence is clear. Basically you are creating a situaiton in the body like when you haven't eaten for a while. The increased sympathetic activation releases stored glycose and fat and shifts to fat-burning. Seriously, the stuff is a great drug for increasing fat loss on a diet. Although that isn't to say it is very effective if you are overweight and not restricting calories, although it should increase metanolic rate and reduce hunger a bit, but it does more when you are skinny/excercising, because that is when alpha2 autoreceptors are more improtant.. Whereas antihistamines give you turbomunchies.
> The claim that 5-ht2c strongly impacts appetite seems dubious because the effects it would predict, such as SSRIs causing weight-loss, have not proved true. A weight-loss drug that targeted 5-ht2c was recently rejected by the FDA. Evidently the effect was marginal.
i wouldn't say its strong, no
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