Posted by desolationrower on May 2, 2011, at 4:04:39
In reply to Re: Mirtazapine and blood sugar » desolationrower, posted by mtdewcmu on May 1, 2011, at 16:54:46
> >
> > no i think the mechanistic evidence is clear. Basically you are creating a situaiton in the body like when you haven't eaten for a while. The increased sympathetic activation releases stored glycose and fat and shifts to fat-burning. Seriously, the stuff is a great drug for increasing fat loss on a diet. Although that isn't to say it is very effective if you are overweight and not restricting calories, although it should increase metanolic rate and reduce hunger a bit, but it does more when you are skinny/excercising, because that is when alpha2 autoreceptors are more improtant.. Whereas antihistamines give you turbomunchies.
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> > > The claim that 5-ht2c strongly impacts appetite seems dubious because the effects it would predict, such as SSRIs causing weight-loss, have not proved true. A weight-loss drug that targeted 5-ht2c was recently rejected by the FDA. Evidently the effect was marginal.
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> > i wouldn't say its strong, no
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> So you think the pro-appetite effect of mirtazapine has more to do with the antihistamine effect? I haven't noticed such a potent reaction to other antihistamines. I am impressed with what mirtazapine did to me. I was underweight for my entire adult life prior. But it may have in part coincided with some effect of hitting 30.well, the one thing i would say that might cause alpha2 antagonism to increase appetite is that if it reduces your depression, and ahedonia from depression caused you to eat less, then unfucking that might cause weight gain. but that is true for any antidepressant.
Mirtazapine is a really strong antihistamine. But i think the 5h2 is important too. The 5ht3 antagonism might add a little bit, it doesn't increase appetite per se but does reduce nausea.
-d/r
Better living through chemistry, socialism, and big phallic rockets (with a side of roquette)
poster:desolationrower
thread:984165
URL: http://www.dr-bob.org/babble/20110502/msgs/984326.html