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Re: For serious 5ht2C-antagonism, LOW doses are needed

Posted by desolationrower on April 7, 2011, at 17:28:14

In reply to Re: For serious 5ht2C-antagonism, LOW doses are needed, posted by Brainbeard on April 7, 2011, at 15:06:16

> >I'm not convinced about the 'only need a little antagonism for a significant effect'.
> I'm not convinced of your counter-arguments either, mostly because I don't understand them. :)
> Agomelatine is an effective 5HT2C-antagonist, right? Interestingly, the Ki value for agomelatine's binding affinity to the 5HT2C receptor is way higher than Prozac's: it's 710nM! ( This means that agomelatine's binding affinity for the 5HT2C-receptor is WWWWWWAAAYYYYYYYYYYY lower than fluoxetine's. It'd better be true that only a little antagonism of 5HT2C-receptors yields significant effects, or agomelatine's supposed 5HT2C-antagonism is a scam.

i hadn't seen those values before.

its more likely that the regular dose of agomelatine is just acting to induce deep sleep


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