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Re: For serious 5ht2C-antagonism, LOW doses are needed

Posted by Brainbeard on April 7, 2011, at 15:06:16

In reply to Re: For serious 5ht2C-antagonism, LOW doses are needed, posted by desolationrower on April 6, 2011, at 16:35:59

>I'm not convinced about the 'only need a little antagonism for a significant effect'.

I'm not convinced of your counter-arguments either, mostly because I don't understand them. :)

Agomelatine is an effective 5HT2C-antagonist, right? Interestingly, the Ki value for agomelatine's binding affinity to the 5HT2C receptor is way higher than Prozac's: it's 710nM! (http://www.medicographia.com/html/static/html/issues/article_latest.asp?page=issues/99/art_10/p_2) This means that agomelatine's binding affinity for the 5HT2C-receptor is WWWWWWAAAYYYYYYYYYYY lower than fluoxetine's. It'd better be true that only a little antagonism of 5HT2C-receptors yields significant effects, or agomelatine's supposed 5HT2C-antagonism is a scam.


Current meds: clomipramine 225mg, fluvoxamine (Luvox) 50mg, dexamphetamine 5-10mg, bethanechol 20-60mg. As needed/wanted: oxazepam 5-20mg.


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poster:Brainbeard thread:982000
URL: http://www.dr-bob.org/babble/20110406/msgs/982197.html