Posted by mtdewcmu on April 5, 2011, at 20:16:04
In reply to It seems Ago + Prozac is the perfect match BUT..., posted by Agomelatinehope on April 5, 2011, at 7:07:48
> I have to point out that I only felt this effect when switching from
> fluoxetine (Prozac) to Agomelatine.
I had a similar experience. I took Paxil for about a month and had horrendous side effects. Then I suddenly switched from Paxil to Remeron and a low dose of Zoloft, and I felt amazing for about a week. Remeron is a 5-ht2c antagonist just like Agomelatine. I don't think the positive feelings had anything to do with the low dose of Zoloft. I think it was stopping Paxil, possibly enhanced by Remeron.
I have not been able to reproduce that feeling on any combination of meds. My feeling is that it had more to do with getting off an SSRI than the meds I switched to, although Remeron may have enhanced it somehow. I also felt pretty good one time after abruptly stopping Prozac and going med-free.
Sad to say, my friend, that I think if you try to recreate that experience permanently, you will be disappointed. My best guess is that it is related to the sudden relief of SSRI side effects, possibly amplified by the blocking of 5-ht2c that the other drug provides.