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Re: Valdoxan (Agomelatine) Combinations » beyondcrazy

Posted by Ron Hill on January 1, 2011, at 1:29:39

In reply to Valdoxan (Agomelatine) Combinations, posted by beyondcrazy on December 28, 2010, at 7:14:07

BC,

> I would like to try Cymbalta and Valdoxan.

The use of Cymbalta and Valdoxan together is contraindicated (i.e.; a no-no) because both meds are metabolized by cytochrome P450 1A2 (CYP1A2).

Here is a link to the Valdoxan Prescribing Information Document:

http://www.servier.co.uk/pdfs/Valdoxan_SPC.pdf

Read Sections: 4.3, 4.4 Subsection - Combination with CYP1A2 inhibitors, and 4.5.

Here is a link to a more comprehensive Valdoxan Prescribing Information Document and other Valdoxan information. Click the "Doctor" option to access the most comprehensive information.

http://www.valdoxan.co.uk/landing.aspx?redirect=/Default.aspx

Here is a link to the Cymbalta Prescribing Information Document:

http://pi.lilly.com/us/cymbalta-pi.pdf

Read Sections: 5.10, 7, 7.1, 7.2, 7.8, and 12.3.

Discuss this CYP1A2 issue with your p-doc. The bottom line is that since both Valdoxan and Cymbalta are metabolized by CYP1A2, the blood levels of one or both will likely be altered from what would ordinarily be expected from the oral dosages.

I take 12.5 mg/night of Valdoxan and it stopped my bipolar II ultra rapid cycling and bipolar II depression, when nothing else ever has.

Below is a list of what I take.

-- Ron

dx: Bipolar II and mild OCPD

600 mg/day Trileptal (oxcarbazepine)
200 mg/day Lamictal (lamotrigine)
500 mg/day Keppra (levetiracetam)
90 mg/day Nardil (phenelzine)
12.5 mg at betime Valdoxan (agomelatine)
3.75 mg/day Deplin (taken with 2500 mcg/day of sublingual methyl B-12, and 12.5mg/day of sublingual P-5-P)
2.5 mg/day Adderal XR

45 ml/day of Carlsons Bottled Fish Oil
100 mg/day phosphatidylserene
1 Centrum Chewable Multi-vitamin/day; Only 100% of all the usual vitamins; NO VANADIUM!!
2000 IU/day Vitamin D-3
850 mg/day of Mg 212% of RDA (as 5 grams of Mg Malate)
200 mcg/day GTF Chromium
600 mcg/day Chromium Picolinate
200 mg/day Co-Q10
1000 mg/day Cinnamon
480 mg/day Milk Thistle
2 g Vitamin C

Whats next to add?:
NAC, + 8 to 10 glasses of water, + Acetyl-L-Carnitine, + Alpha-Lipoic Acid



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