Posted by beyondcrazy on January 1, 2011, at 2:24:15
In reply to Re: Valdoxan (Agomelatine) Combinations » beyondcrazy, posted by Ron Hill on January 1, 2011, at 1:29:39
> BC,
>
> > I would like to try Cymbalta and Valdoxan.
>
> The use of Cymbalta and Valdoxan together is contraindicated (i.e.; a no-no) because both meds are metabolized by cytochrome P450 1A2 (CYP1A2).
>
> Here is a link to the Valdoxan Prescribing Information Document:
>
> http://www.servier.co.uk/pdfs/Valdoxan_SPC.pdf
>
> Read Sections: 4.3, 4.4 Subsection - Combination with CYP1A2 inhibitors, and 4.5.
>
> Here is a link to a more comprehensive Valdoxan Prescribing Information Document and other Valdoxan information. Click the "Doctor" option to access the most comprehensive information.
>
> http://www.valdoxan.co.uk/landing.aspx?redirect=/Default.aspx
>
> Here is a link to the Cymbalta Prescribing Information Document:
>
> http://pi.lilly.com/us/cymbalta-pi.pdf
>
> Read Sections: 5.10, 7, 7.1, 7.2, 7.8, and 12.3.
>
> Discuss this CYP1A2 issue with your p-doc. The bottom line is that since both Valdoxan and Cymbalta are metabolized by CYP1A2, the blood levels of one or both will likely be altered from what would ordinarily be expected from the oral dosages.
>
> I take 12.5 mg/night of Valdoxan and it stopped my bipolar II ultra rapid cycling and bipolar II depression, when nothing else ever has.
>
> Below is a list of what I take.
>
> -- Ron
>
> dx: Bipolar II and mild OCPD
>
> 600 mg/day Trileptal (oxcarbazepine)
> 200 mg/day Lamictal (lamotrigine)
> 500 mg/day Keppra (levetiracetam)
> 90 mg/day Nardil (phenelzine)
> 12.5 mg at betime Valdoxan (agomelatine)
> 3.75 mg/day Deplin (taken with 2500 mcg/day of sublingual methyl B-12, and 12.5mg/day of sublingual P-5-P)
> 2.5 mg/day Adderal XR
>
> 45 ml/day of Carlsons Bottled Fish Oil
> 100 mg/day phosphatidylserene
> 1 Centrum Chewable Multi-vitamin/day; Only 100% of all the usual vitamins; NO VANADIUM!!
> 2000 IU/day Vitamin D-3
> 850 mg/day of Mg 212% of RDA (as 5 grams of Mg Malate)
> 200 mcg/day GTF Chromium
> 600 mcg/day Chromium Picolinate
> 200 mg/day Co-Q10
> 1000 mg/day Cinnamon
> 480 mg/day Milk Thistle
> 2 g Vitamin C
>
>
> Whats next to add?:
> NAC, + 8 to 10 glasses of water, + Acetyl-L-Carnitine, + Alpha-Lipoic Acid
>
>
>
>
>Thank you for the info and links.
Wow! Thats quite a cocktail your on there.
B.C.
poster:beyondcrazy
thread:975023
URL: http://www.dr-bob.org/babble/20101231/msgs/975449.html