Posted by orbital on November 16, 2010, at 20:06:41
In reply to Re: 7 days, posted by morgan miller on November 16, 2010, at 13:26:00
> >If this trend continues, I'll consider going off Paxil to see how agomelatine works on its own. So far so good.
>
> Are you concerned that there is some synergy here and you may not feel as well on Paxil? I'm always worried that if drugs like SSRIs work and I stop them, they may not work as well when I try to get back on them. If you don't have any unwanted side effects from Paxil, I would not get off it.
>
> I'm guessing Paxil has given you the most benefit of all the SSRIs and you have given them all a good shot.
>Well, actually I'm thinking about the flipside: what if Paxil is hampering the agomelatine?
I have no reason to suspect this might be the case, but at some point I'd like to try Valdoxan on its own.
About meds not working the second time around... my old doc told me that the brain's biochemistry changes over time (for better or worse this is the long term aim of pharmacotherapy of course) so certain meds may "feel" different when rechallenged. For instance, several years ago I was on bupropion for a good 8 months with little to no problems; when I tried it again last year, I was unable to tolerate it. Doc's theory being, it's not the med itself that has changed, but the person's biochemical makeup.
Anyway, of all the SRIs, Paxil is a fair middle ground for me: no noteworthy side effects, and reasonably effective for both depression and anxiety.
poster:orbital
thread:968721
URL: http://www.dr-bob.org/babble/20101107/msgs/970527.html