Posted by ggggg123 on November 7, 2010, at 15:28:54
In reply to Re: Who has taken an NRI long-term??, posted by Conundrum on November 7, 2010, at 14:00:00
ye you might be right conundrum, I'm still taking my dwindling supply of wellbutrin with a small amount of bromocriptine. As I need to replace the wellbutrin as I don't want to pay for it. I will be getting the drugs on prescription, as we have a national health service so all drugs are a fixed cost of £7.50, so generics are pretty much always used, if they are available. The only thing is i really don't want to increase serotonin directly, but I suppose I may have to, also I imagine the half life is much longer on the tca's, I think the reason reboxetine was found ineffective is most people seem to respond to serotonin, I am the opposite, I may be in a small subset, but my depression is defo more norep and dop and always was but ssri's made it even more so. It is estimated that only a small subset of depressed people need norepinephrine and dopamine, wouldn't this account for some of the ineffectiveness reported?
I only want to try the drugs with the least serotonergic properties. This is why I would like to try reboxetine not so much because of the anticholinergic.
But I suppose nortriptyline and desimpramine have relatively weak serotonergic activity.
Maybe a tca would be the best option, at this moment in time I don't care I just want some norepinephrine lol
Its abit of a dilemma, I kinda just want to get back active and interested in life, then I hope the rest will fall into place and the brain my start to heal.
My theory is that ssri's treat people with emotional and personality disorders, whilst those with endogenous depression have a large norepinephrine component, if a person with severe endogenous depression takes an ssri, they become even more anhedonic, they lose every last bit of nor and dop, whilst a person with high emotions and hysteria, would feel much better and relaxed. Only my theory. Maybe it is the broad definition of depression that is at fault in these trials and not the actual drug. If a person with normal norepinephrine levels takes an nri, it would be hell, like you've just drank 10 espressos, but a person with non may feel normal.
poster:ggggg123
thread:968983
URL: http://www.dr-bob.org/babble/20101107/msgs/968995.html