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Re: Who has taken an NRI long-term??

Posted by ggggg123 on November 8, 2010, at 12:34:39

In reply to Re: Who has taken an NRI long-term??, posted by ggggg123 on November 8, 2010, at 10:31:22

No body has ever proven that serotonin plays a role in depression, at least not a major role. Do people just feel better on ssri's or do they feel completely normal?, remission? responder? all means nothing, flawed with subjectivity. The only good test would be that a patient is fully functioning and is fulfilled in every aspect of his/her life, unless they have organic constraints.
Another theory could be that ssri's help a person feel better whilst the body recovers from depression naturally.
Mild depression is completely different from severe depression, the body can heal in a matter of months with moderate depression, I've seen it first hand. Severe depression is a new ball game and one could argue it is these patients who may respond to ne*. In other patients it may be excessive and adverse reactions like heart palps,sweating and panic. I don't think any evidence suggests that norepinephrine is inhibitory, therefore maybe it is does not attenuate other neuro systems and is why a selective serotonin drugs, no matter which one can cause post drug anhedonia. The ssri's are chemically unrelated but all have similar effects on serotonin, therefore would it not be safe to say the main causal factor precipitating our unfortunate outcome, would be serotonin itself and not the properties of the drug. and is it not chronic inhibition which attenuates NE in a vulnerable depressed brain and then leaves the brain ne deficient, with very low ne processing. Maybew this is why the complaint is less with the tca, as the equilibrium they pprovide with both SE/NE provents this inhibition and thus prevents diminished ne processing. Fluoxetine, what you took is unrelated to citalopram which I took, but they both intensify serotonergic neurotransmission, with this being the only common link, in our identical symptom syndrome, it is this action that is fundamentally responsible. I think for people with anhedonia the ratio should be something like 1:5 serotonin to noradrenaline, maybe at a push a tca with the lowest affinity for serotonin may prove beneficial.
Do you not think that these drugs are mostly serotonergic because it makes them safer, easier to dose, therefore much easier to get fda approvable, they can be marketed to a mass audience unlike nris, ndris and maoi,s, therefore the reason serotonin is at the forefront of being causative in "depression" is due to a variety of profitability and societal/official acceptability.

NDRI'S do not sell well, gp's rarely prescribe them, but for the severely depressed anergic people they might be life changing.

You can't dish out nri's they cause anger, mania and anxiety if the dose is slightly to high, with the small window of therapeutic benefits, whilst things can go down hill pretty quickly if thew dosing is wrong, much more quickly and much worse than if the ssri is too high.

Is it not these factors which have lead to ssri's being at the forefront of treating depressive illness?

I think low dose nri, maybe a dopaminergic combined with a good healthy lifestyle. Especially for people with anhedonia. Anhedonia is a horrible state to be in, people don't understand the severity of the condition, you are stuck in no mans land, you feel nothing, you have no life, yet you are alive and walking like everybody else. In my opinion its one of the worst conditions, and really deserves effective treatment.


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