Posted by SLS on August 16, 2010, at 5:36:08
In reply to Re: RIMAs vs MAOIs » SLS, posted by ed_uk2010 on August 15, 2010, at 16:06:49
> Hi Scott,
>
> >My experience with clorgyline is that it was more effective than Nardil or Parnate at a time when I was totally resistant to everything else.
>
> Do you know whether clorgyline is still available anywhere?It is no longer available anywhere for human consumption. It is used today as the standard ligand for assaying MAO-A activity in the lab.
> Also, what mechanism could explain its possibly superior efficacy?
I really don't know. Perhaps MAO-B inhibition is somehow counterproductive. I don't think it is unreasonable to categorize MAO-A as the enzyme of depression and MAOI-B as the enzyme of Parkinsonism. Several older studies found that MAO-A will actually metabolize dopamine in certain brain regions. At least one newer study contradicts this, though.
> Perhaps it was better tolerated than Nardil or Parnate, and that might allow a particularly high dose to be given.
Clorgyline is a potent drug. 5-10mg will often be all that is necessary to elicit an antidepressant response. I found it to be quite tolerable at 15mg. Dosages of 30mg of clorgyline had been used on children to investigate its utility in ADD/ADHD. My guess is that increased tolerability is not a factor in the superior therapeutic properties of clorgyline.
> The new drug TriRima, mentioned above by Tomatheus, sounds quite interesting. Apparently, it is more potent than moclobemide.
Wow. I would try it.
> http://www.cenerx.com/Products/rima-data.html
Thanks for the link.
- ScottThe measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:958646
URL: http://www.dr-bob.org/babble/20100811/msgs/958804.html