Posted by ed_uk2010 on August 16, 2010, at 15:50:14
In reply to Re: RIMAs vs MAOIs » ed_uk2010, posted by Tomatheus on August 15, 2010, at 16:12:00
>Am I allowed to respond?
Yes, of course. Why would you think that you might not be allowed to?!
You make some excellent points. Now about moclobemide... I've been wondering whether the problem with moclobemide is not its reversibility, but its very short duration of action. It has an extremely short half life and I suspect that it does not consistently inhibit MAO-A across day, despite twice a day dosing. On average, moclobemide's half-life is about 3 hours. In some patients, it is as little as 2 hours. For a *reversible* inhibitor of MAO, how can this be adequate?
I wonder whether moclobemide would be more effective if given more frequently? 150mg four times a day might work.
poster:ed_uk2010
thread:958646
URL: http://www.dr-bob.org/babble/20100811/msgs/958835.html