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Re: RIMAs vs MAOIs

Posted by SLS on August 15, 2010, at 9:20:27

In reply to Re: RIMAs vs MAOIs, posted by Tomatheus on August 15, 2010, at 8:55:09

> I could be wrong, but my guess is that moclobemide is less effective than Nardil and Parnate because it's reversible, not because it's selective to MAO-A. Selegiline primarily inhibits MAO-B, but begins to exert antidepressant activity at doses that inhibit MAO-A. This, coupled with a study that found clorgyline (an irreversible MAO-A inhibitor) to be a more effective antidepressant than pargyline (an irreversible MAO-B inhibitor), actually supports the notion that MAO-A inhibition is more important than MAO-B inhibition when it comes to the treatment of depression. I personally think that an antidepressant that inhibits MAO-A both selectively and irreversibly would be more effective than any MAOI or RIMA (or possibly even any antidepressant) that's currently available. Unfortunately, no such antidepressant has ever been made available as a prescription antidepressant, as far as I'm aware.

I agree with everything you have written here.


- Scott


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but in how hard the climb.

The measure of success lies only in how high one feels he must
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URL: http://www.dr-bob.org/babble/20100811/msgs/958659.html