Posted by linkadge on July 25, 2010, at 21:32:32
In reply to Re: toxic crap » SLS, posted by bleauberry on July 25, 2010, at 20:25:37
>Drugs almost for sure didn't do you any favors, >but they didn't make you treatment resistant.
I disagree completely. What is so different from these drugs and street drugs? If you're taking SSRI's + Ritalin you're pretty much taking cocaine.
These drugs do alter the brain, and there is plenty of research to support this. I totally think long term use can lead to treatment resistance.
- Drugs altering neuroendocrine function.
Persistant alterations in neuroendrocrine
function could cause treatment resistance.
- TCA's unfavorably altering metabolic function
(abnormal insulin sensitivity can itself promote
depression)
- TCA's and SSRI's are associated with white
matter atrophy - (see 1)
- SSRI's in vitro cause motor neuron death (2)
in the study below paroxetine is much more
toxic to motor neurons than fluoxetine.
- In vitro, AD's can depleat neurotransmitter
neurotransmitter levels. The study below
links citalopram to decreased serotonin
synthesis. Also - you're not really "restoring"
dopamine by taking a stimulant with an SSRI. (3)
- Sertraline is pro-oxidant when taken with
anticonvulsants (4). Would this extend to other
SSRI's.
You can go on and on.Every drug takes its toll.
1.
http://stroke.ahajournals.org/cgi/content/full/39/3/857
2.
3.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006797
4.
http://medind.nic.in/ibi/t04/i1/ibit04i1p43.pdf
Linkadge
poster:linkadge
thread:955512
URL: http://www.dr-bob.org/babble/20100720/msgs/955909.html