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Re: Who's taking Seroquel for (bipolar) depression? » morganator

Posted by bleauberry on March 12, 2010, at 19:56:38

In reply to Re: Who's taking Seroquel for (bipolar) depression? » bleauberry, posted by morganator on March 12, 2010, at 2:06:07

> Just curious, why do you think amulsipride is so much better than all the AP's including zyprexa?

Well, if we look at the positive symptoms of schizophrenia, amisulpride does not show a statistical advantage over any of the other APs. If we however look at the negative symptoms of schizophrenia, amisulpride shows a clear statistical advantage in almost every head to head clinical study. It also showed faster onset and more thorough effect on depressive symptoms when compared head to head with ssris. Negative symptoms are very similar to depression, almost indistinguishable.

Amisulpride is also commonly prescribed as monotherapy for major depression, dysthymia, and double depression. I don't know of any other APs that can do that.

But that's all literature stuff from pubmed. In the realworld, I have tried zyprexa, abilify, and seroquel myself. I was on zyprexa for years. So I know APs pretty well. We go way back, you could say. I can only say from my own personal experience, amisulpride is a totally different animal. It stands above them all. It has unique mechanisms that can be changed with dose size. While other APs hit a wide variety of receptors, amisulpride hits D2, D3, and the recent discovery of 5ht7. Based on analgesic effects on rats blocked by antiopiod meds, the assumption is that it also has some interplay with the opioid system. Basically a very clean med.

All I know is, it works! And fast.

Not bad for someone who failed ECT. Gosh, no other APs could do that for me. So how could I NOT speak highly of it.

Mileage varies.


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