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Re: Prozac and dysphoria and - or norepinephrine

Posted by Garnet71 on August 22, 2009, at 10:57:40

In reply to Re: Prozac and dysphoria and - or norepinephrine, posted by SLS on August 22, 2009, at 9:36:45

Thanks for all the information, everyone. Scott, I think you're correct; I never did plan this combination but was hesitant to give up the buspirone. It does seem like an odd combination. Interesting that a neuro-psych with whom I recently consulted had mentioned the possibility of Remeron. But Remeron seems to be the "eat and sleep drug" for many and I can't tolerate any type of anti-histimines, so I'm wondering if Remeron would not be good for me anyway. The consultant doc also mentioned Emasam.

I did recently try Klonopin a few times, but .5 mg just made me feel strange. I can't even describe this strangeness, but it does add a headache and gives me a feeling of tiredness while it doesn't seem to affect my nervous system.

I'm giving up the Prozac because I just can't tolerate the Seratonin affects of SSRIs and a larger dose would most likely facilitate the same effect. After 3 years of trying them, no more. It also made my head and sinuses all stuffy, like I had a cold the whole time I was on it.

This is probably no new news here, but I realized the lack of motivation is a subtype of depression that I was never aware of. I think I'll check into this more. I've experienced long-term chronic stress, and think it's affected me. Well that's just one of several thoughts on the amotivational type of depression. There is still the possibility that psychotherapy will change this state of mind....

Here's some infor. I found if anyone is interested.

"So what's the catch? One problem, to which not all authorities on nootropics give enough emphasis, is the complex interplay between cognition and mood. Thus great care should be taken before tampering with the noradrenaline/acetylcholine axis. Thought-frenzied hypercholinergic states, for instance, are characteristic of one "noradrenergic" sub-type of depression. A predominance of forebrain cholinergic activity, frequently triggered by chronic uncontrolled stress, can lead to a reduced sensitivity to reward, an inability to sustain effort, and behavioural suppression."

Savella for the subtype:

I think I'm going to check into what I've read here, to start:

I might have to give up the Buspirone to go this route. Will have to see what new PDoc says.

For right now, I'm going swimming!





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