Posted by SLS on August 21, 2009, at 17:08:15
In reply to Prozac and dysphoria and - or norepinephrine, posted by Garnet71 on August 21, 2009, at 14:56:32
Hi Garnet.
After writing this, I question how helpful it is. Maybe the information will allow you to figure things out for yourself. I don't seem to be able to. Your thoughts are sophisticated and relevant.
At low dosages, Prozac blocks 5-HT2c receptors more than it does inhibit the reuptake of serotonin. This results in an elevation of DA and NE in the prefrontal cortex. At higher dosages, elevated synaptic concentrations of serotonin compete for the receptors and can reverse the influences that Prozac has on them. I cannot venture a guess as to how this might relate to your experience with this drug.
I think your looking at norepinephrine might be justified. Perhaps your system is being influenced by buspirone. Although buspirone has no direct effect on NE, its metabolite, 1-PP, does. It acts very much like Remeron as an antagonist of NE alpha-2 presynaptic autoreceptors. This tends to increase the synthesis and release of NE. Perhaps there is some sort of synergy going on between the two drugs that is yielding the dysphoria that you are experiencing.
Have you ever tried Remeron? If so, how did it affect you?
- Scott
poster:SLS
thread:913355
URL: http://www.dr-bob.org/babble/20090818/msgs/913368.html