Posted by Alexanderfromdenmark on June 15, 2009, at 10:06:38
In reply to Re: Is It Possible Bioidenticals Missing Link Depressi » Alexanderfromdenmark, posted by Phillipa on June 14, 2009, at 20:20:17
> Oh how right you are on the thyroid. It effects your whole body and mind. Fine til mine went. All the hormones are intertwined. So difficult to understand. Phillipa
"Thyroxine should be tried in clinically hypothyroid but biochemically euthyroid patients (Skinner GRB, Thomas R, Taylor M, Sellarajah M, Bolt S, Krett S, et al. BMJ 1997; 314: 1764)
We wish to question present medical practice, which considers abnormal serum concentrations of free thyroxine and thyroid stimulating hormonethose outside the 95% reference intervalto indicate hypothyroidism but incorrectly considers "normal" free thyroxine and thyroid stimulating hormone concentrations to negate this diagnosis. It is unusual for doctors to start thyroxine replacement in clinically hypothyroid but biochemically euthyroid patients.
The free thyroxine and thyroid stimulating hormone concentrations in 80 patients considered to be hypothyroid on established criteria indicated that only five patients had free thyroxine concentrations (just) below the reference interval of 10-19 pmol/l (values of 9.4, 9.8, 9.8, 9.9, and 9.9 pmol/l) and only four patients had thyroid stimulating hormone values above the reference interval of 0.5-5.5 mU/l (values of 5.6, 8.4, 11.8, and 30.1 mU/l); moreover in these 80 patients the mean (SE) concentration of free thyroxine was 12.9 (0.2) pmol/l and the mean concentration of thyroid stimulating hormone was 2.2 (0.4) mU/l; both of these values lie well within the normal reference intervals. While we accept that there will be subjective variation in the evaluation of clinical diagnostic criteria and that the long term response to thyroid replacement is a prerequisite of our proposition, exclusion of hypothyroidism on the grounds of hormone concentrations measured in the laboratory seems wrong.
We contend that an incremental three month trial of thyroxine treatment in clinically hypothyroid but biochemically euthyroid patients is a safe and reasonable strategy. The dangers of osteoporosis and cardiac catastropheparticularly during a three month trialare sometimes quoted, but these worries are unfounded and condemn many patients to years of hypothyroidism with its pathological complications and poor quality of life. We urge that the question of clinical hypothyroidism in biochemically euthyroid patients should be subjected to a formal clinical trial."Goes to show that when your go to your doc and it says that your thyroid is normal it dosn't mean squat if he says that because of blood tests alone.
poster:Alexanderfromdenmark
thread:900723
URL: http://www.dr-bob.org/babble/20090611/msgs/901103.html