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Re: OCD - Just a thought. » johnj1

Posted by SLS on May 2, 2009, at 8:47:55

In reply to Re: OCD - Just a thought. » SLS, posted by johnj1 on May 2, 2009, at 8:25:38

> Wouldn't serotonin meds work then because they would cut off the dopamine circuit?

I am guessing that those are thoughts that occurred to the investigators.

> If you use a dopamine med wouldn't that leave you with less dopamine and serotonin then?

You probably know more than me about this stuff. How does a atypical neuroleptic (antipsychotic) reduce serotonin activity? I know that they block 5-HT2a receptors, but that is not the same as producing a global reduction in serotoninergic tone. The downregulation of somato-dendritic 5-HT1a autoreceptors is probably important to increase tone. You would need an SRI antidepressant for that to occur. I think it is the combination of drugs that is necessary to produce a synergistic effect that might help people with treatment-resistant OCD.

Maybe Prozac + Risperdal?


- Scott

 

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