Posted by sowhysosad on April 3, 2009, at 17:12:18
In reply to Re: Bupropion - norepinephrine uptake, posted by desolationrower on April 3, 2009, at 4:09:38
> oh, theres also amantadine. many of these are availible via less than reputable means.
>
> And nicotine is actually a pretty good dopaminergic.
>
> And for non-dopaminergic antiakithisia meds, cyproheptadine and clonidine have been used (5ht antagonist makes more sense given that an ssri is causing it).
>
> theres no clear answer on what bupropion does; theres not much incentive to research it as its off patent and all, though one metabolite was looked into a bit. conventional wisdom is NA/DA reuptake inhibitor, theres some theorizing that its an NE releaser, and i think its mostly tnf-alpha inhibitor, and the da does a little bit.
>
> -d/rThanks d/r. Funny you should mention nicotine, as I've been smoking a fair few cigs every day this week. And I've started dabbling with caffeine after abstaining for months, plus doing some moderate exercise.
The net result is that I felt quite agitated at times yesterday and today, and I've had a raging libido. That would suggest high dopamine, wouldn't it? And yet my movement disorder seems unchanged.
If I was to get akathisia again, its recognition seems so poor in the UK that they'd probably just give me a week's low dose diazepam again.
poster:sowhysosad
thread:887980
URL: http://www.dr-bob.org/babble/20090330/msgs/888539.html