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Re: Fluoxetine/sertraline and dopamine

Posted by sowhysosad on April 2, 2009, at 9:54:59

In reply to Re: Fluoxetine/sertraline and dopamine » sowhysosad, posted by raisinb on April 2, 2009, at 9:18:25

> I'd go with the Zoloft first. Here is a last-ditch idea--do they prescribe Zyban for smoking cessation? It's the same as Wellbutrin. Of course, it is never a good idea to start smoking if you don't already, but if buproprion is truly the answer for you, perhaps that's worth a shot.

I'd contemplated going down that route, and coincidentally I have started smoking again recently.

However, I've read that Zyban/Welbutrin's active metabolite is more powerful than the drug itself and causes largely norepinephrine reuptake rather than that of dopamine, so overall it boosts the former way more than the latter. So I'd be back to the norepinephrine "sense of impending doom" and heightened startle reflex which has made imipramine so unpleasant.


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