Posted by sowhysosad on April 8, 2009, at 17:01:08
In reply to Re: Fluoxetine/sertraline and dopamine, posted by desolationrower on April 8, 2009, at 8:24:48
> haven't really looked into mnovement disorders but why would 5htp not exacerbate it if ssris would?
>
> -d/rI'm guessing that 5HTP wouldn't interfere with other systems in the brain like SSRI's do, like the aforementioned D2 supersensitivity issue. 5HT2A/C agonism from SSRI's could also be a factor, plus there's a theory that they may also cause movement disorders by acting on sigma 2 receptors in the red nucleus.
I'm also guessing it would also be easier to fine-tune serotonin levels with 5HTP, rather than arbitrarily flooding the synaptic gap as SSRI's often do. Presumably this would make it easier to strike a balance with dopamine, as its release wouldn't be mediated by the abnormally high serotonin levels.
poster:sowhysosad
thread:887980
URL: http://www.dr-bob.org/babble/20090408/msgs/889517.html