Posted by SLS on August 26, 2008, at 14:37:46
In reply to Re: Parnate trial, posted by desolationrower on August 26, 2008, at 13:38:58
> Do you think it is doing something besides blocking histamine receptors?
I am really not sure. I was hoping you could elucidate for me.
Low-dosage Seroquel seems to be a better hypnotic than doxepin from what people report here on PB; doxepin being a very potent H1 antagonist. It is an order of magnitude more potent than Seroquel.
Seroquel hits many receptors as an antagonist according to the PDSP database. I would be hard pressed to pick one out as singularly responsible for its sedative effects. I'm sure the H1 antagonist property figures in to the overall sedation, though.
- Scott
poster:SLS
thread:847722
URL: http://www.dr-bob.org/babble/20080822/msgs/848432.html