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Re: Parnate trial desolationrower

Posted by SLS on August 26, 2008, at 14:37:46

In reply to Re: Parnate trial, posted by desolationrower on August 26, 2008, at 13:38:58

> Do you think it is doing something besides blocking histamine receptors?

I am really not sure. I was hoping you could elucidate for me.

Low-dosage Seroquel seems to be a better hypnotic than doxepin from what people report here on PB; doxepin being a very potent H1 antagonist. It is an order of magnitude more potent than Seroquel.

Seroquel hits many receptors as an antagonist according to the PDSP database. I would be hard pressed to pick one out as singularly responsible for its sedative effects. I'm sure the H1 antagonist property figures in to the overall sedation, though.


- Scott

 

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