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Re: Parnate trial desolationrower

Posted by SLS on August 25, 2008, at 9:04:11

In reply to Re: Parnate trial SLS, posted by desolationrower on August 23, 2008, at 20:02:04

> I think the lack of benefit over other agents, plus antihistimines cause metabolic problems if used over time. They don't even promote good sleep. Quetiepine at low doses probably doesn't affect d2 and so has a low chance of the neuroleptic side effects, but that also means its got zero benefit (also probably not affecting 5ht2a). Still, higher doses do have that effect.

If I'm not not mistaken, I believe Seroquel blocks 5-HT2a receptors at lower concentrations than it does for DA2 receptor blockade to become signicant.

Interestingly, the active metabolite of Seroquel is a medium potency NE reuptake inhibitor, which might explain why Seroquel produces less sedation at higher dosages as well as producing an antidepressant effect. I gravitate towards using this drug as an anxiolytic or hypnotic at dosages of 25mg PRN.

- Scott




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