Posted by undopaminergic on April 2, 2008, at 3:18:59
In reply to Re: Medication adjustment - Remeron, posted by Molybdenum on March 30, 2008, at 16:49:00
In my experience mirtazapine (genergic Remeron) is more than dangerous enough on its own - no augmentation required. I was only taking 15 mg (or 7.5 mg? I don't remember), but I was having 24 h tachycardia and after meals it would get worse: my motor coordination would dissipate, my voice become dysarthric and there would be stiffening/cramping of neck and facial muscles. I don't think I've ever been so "drunken". I had to quit it in only a few days, which is sooner than for any other drug I've taken.
I suspect the problem was the blockade of alpha2-adrenergic receptors. These receptors should not be blocked; rather, they should be stimulated, for example with guanfacine, which has a soothing effect on the cardiovasclar system and enhances cognition.
poster:undopaminergic
thread:820209
URL: http://www.dr-bob.org/babble/20080330/msgs/821117.html