Posted by Astounder on November 16, 2007, at 10:43:22
In reply to Re: bupropion compared to NRI's » Astounder, posted by linkadge on November 16, 2007, at 9:33:09
The seizure risk is way overblown, I think. The original clinical trials using instant release Wellbutrin used up to 900 mg/d, and only causes seizure in those with already lowered seizure thresholds (bulimics).
>>I also don't like the idea of DAergic >metabolites floating around when I'm trying to >sleep.
DA&NAergics are known to typically decrease both slow wave and REM sleep, while NAergics themselves just decrease REM. Plus constant D2 receptor stimulation (not breaking while sleeping), is going to cause postsynaptic downregulation. I don't care about their effects on attention, just mood & reward, so the mesolimibic area is most important to me.
>I'm confused by this statement. Are you suggesting that norepinephrine transport does not return to baseline uptake after NRI discontinuation? Or do you only mean shortly after?
I thought so, but I can't find any data on how long the changes last, unfortunately.
poster:Astounder
thread:794699
URL: http://www.dr-bob.org/babble/20071115/msgs/795457.html