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Re: bupropion compared to NRI's » Astounder

Posted by linkadge on November 16, 2007, at 9:33:09

In reply to Re: bupropion compared to NRI's » linkadge, posted by Astounder on November 15, 2007, at 23:37:52

>Wellbutrin had immediately an effect at an acute >900 mg XL dosing, made me giddly and alert.

Geez, I hope you weren't just taking 900mg without working up to it. You could have seized.

>Weakly psychostimulant-like. Since I've read >there is tolerance to its DAergic effects
>(eventual DAT upregulation), I went for >desipramine instead.

Thats a strange reason to choose a drug switch. I had read that DAT upregulation occured in the neucleus accumbens but not in other brain regions. Burpropion is also supposedly has higher affinity for NET in humans than DAT.

>I also don't like the idea of DAergic >metabolites floating around when I'm trying to >sleep.

So it gave you insomnia?

>Both of them cause plastic NET downregulation >after a few weeks, like all other NAergic >antidepessants. An effect that remains after >treatment ends

I'm confused by this statement. Are you suggesting that norepinephrine transport does not return to baseline uptake after NRI discontinuation? Or do you only mean shortly after?

Linkadge


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URL: http://www.dr-bob.org/babble/20071115/msgs/795452.html