Posted by Astounder on November 15, 2007, at 23:37:52
In reply to bupropion compared to NRI's, posted by linkadge on November 12, 2007, at 19:01:51
> Has anyone taken both bupropion and an NRI? Can anyone compare bupropion to say nortryptaline or desipramine?
>
> Thanks
>
> LinkadgeWellbutrin had immediately an effect at an acute 900 mg XL dosing, made me giddly and alert. Weakly psychostimulant-like. Since I've read there is tolerance to its DAergic effects (eventual DAT upregulation), I went for desipramine instead. I also don't like the idea of DAergic metabolites floating around when I'm trying to sleep.
Desipramine 100 mg did nothing for me, even chronically, except cure my heartburn and cause some awesome hallucinations.
Both of them cause plastic NET downregulation after a few weeks, like all other NAergic antidepessants. An effect that remains after treatment ends.
poster:Astounder
thread:794699
URL: http://www.dr-bob.org/babble/20071115/msgs/795398.html