Posted by aqua1221 on July 7, 2007, at 12:05:27
In reply to Re: dextroamphetamine causing depression? » aqua1221, posted by revaaron on July 5, 2007, at 17:55:49
> aqua- what you say definately makes sense. Ritalin causes depression in some folks, but not others, and generally less than with the amphetamines. Before Kaye's incredibly helpful advice, I was considering trialing ritalin when the dex was causing depression. The reason is pretty straightforward: ritalin is a reuptake inhibitor of dopamine and norepinephrine, while the amphetamines cause dopamine and norepinephrine to be released. Ritalin increases the amount of them in your brain by stopping the process that takes them out of circulation, amphetamines force the reserves out, when they're then taken back up like in an drugless brain. When the neurotransmitters are pushed out, your body has to make more to replenish the supply for the amphetamine to do it again. Some people, possibly because of diet or metabolism, can create enough dopamine and norepinephrine to keep a large enough supply, but in others (me) it doesn't seem to be able to keep up without a little help (taking a dopamine and norepinephrine precuror like L-tyrosine or L-phenylalanine). VVyvanse contains lisdexamfetamine which is a inactive prodrug that converts into dextroamphetamine in the body. This is basically chemically modulated extended release formulation of dextroamphetamine, and as such, will likely effect you the same way as dextroamphetamine, including depression.
>
> Have you ever tried straight dextroamphetamine? A lot of folks seem to have better results with it over Adderall, which contains 4 different amphetamine salts.
No, I've only tried Ritalin and Adderall.
poster:aqua1221
thread:766590
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