Posted by psychobot5000 on May 2, 2007, at 14:15:22
In reply to Re: NA/DA meds for motivation, anhedonia, posted by jrbecker on May 2, 2007, at 1:41:04
> > This is good, but let me theorize what might be best: a dopamine reuptake inhibitor with -high- affinity for the nucleus accumbens, which could be bonded to a molecule that would make it inert until processed (and released from the bond) by the liver, at a rate limited by the quantity of liver-enzyme available--just as they've done with amphetamine.
> >
> > Potentially, this might create a drug that might effectively fight anhedonia, without significant abusability. It would be impossible to flood the system with an active form of the chemical.
> >
>
> you basically have a candidate in Vyvanse. it's a reconstituted amphetamine compound from Shire.Vyvanse was what I modeled the idea of this hypothetical med on. It's probably a good idea on their part to prevent abusability, however, amphetamine is far from being a pure DA reuptake inhibitor. Dexamphetamine didn't do that much for me, as it happens--though I have no idea why. ...I guess my hope was that they could use this Vyvanse-type abuse-limiting formulation of drugs, to make it possible to release a dopaminergic drug that in its natural form is much more abusable and euphoric. If the liver-enzyme thing prevented anyone from binging, because the liver only released the drug into active form at a slow rate, perhaps BigPharma could release a powerful dopaminergic drug without upsetting the drug warriors and creating another drug of abuse.
Best,
Psychbot
poster:psychobot5000
thread:754423
URL: http://www.dr-bob.org/babble/20070502/msgs/755211.html