Posted by jrbecker on May 2, 2007, at 1:41:04
In reply to Re: NA/DA meds for motivation, anhedonia, posted by psychobot5000 on May 1, 2007, at 16:17:06
> This is good, but let me theorize what might be best: a dopamine reuptake inhibitor with -high- affinity for the nucleus accumbens, which could be bonded to a molecule that would make it inert until processed (and released from the bond) by the liver, at a rate limited by the quantity of liver-enzyme available--just as they've done with amphetamine.
>
> Potentially, this might create a drug that might effectively fight anhedonia, without significant abusability. It would be impossible to flood the system with an active form of the chemical.
>you basically have a candidate in Vyvanse. it's a reconstituted amphetamine compound from Shire.
It's awaiting labelling authorization by the FDA and is being slated for a june/july launch. If you haven't responded to other ampthetamines in the past though, this will probably not induce drastically different effects. However, if a sustained reponse and/or rebound effects have been issues that have hampered their use by you in the past, then Vyvanse might be somewhat more suitable.
www.fda.gov/cder/Offices/ODS/MG/lisdexamfetamineMG.pdf
poster:jrbecker
thread:754423
URL: http://www.dr-bob.org/babble/20070426/msgs/755080.html