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XR: What Dosage Passes Serotonin Impact?

Posted by SandyWeb on March 3, 2007, at 9:54:44

In reply to Re: Anyone tried the generic Effexor XR? KristiVegas, posted by bear38 on February 25, 2007, at 17:33:54

Hi all,

My brain chemistry problems don't seem to be related to serotonin. We have tried almost every SSRI without success or very weird results to my thinking process. I have tried other meds as well, but am really in need of something with an AD effect. (Jeepers, even a stimulant would be acceptable to me now....as long as it didn't increase my anxiety and insomnia).

I had tremendous success on Remeron at a HIGH dose. I called it my "anti-suicide" drug. It worked wonders. I was on it for two years, but after gaining about 70 pounds and reaching an all-time high of 200 pounds (WOOZY!!!!!!), I just had to quit the medication. I'm happy to say that I'm back down to 130 pounds now (phew!). I am still on clonazepam (3 mg per day) and Lopressor SR (100 mg twice per day) for anxiety. But I need something to help with the depression and suicidal ideation.

I tried Effexor XR (starting at 75 mg daily), and I had high hopes because it's basically in the same class as Remeron. But, of course, the first neurotransmittor it starts impacting is serotonin....and I was going weird in the head again, not to mention having intolerable insomnia that even the clonazepam wasn't helping. I just couldn't handle being "psycho", so I had to quit it after a short time.

I would like to know at what dosage do we get away from the major impact being on serotonin and instead being upon norepinephrine?? As I said, it was a HIGH dose of Remeron that worked so incredibly well for me. I need to stay as far away from serotonin impact as I can. Do you know if Effexor XR at 150 mg or 225 mg is at the dosage I'm trying to locate?

Thanks so much.

Sandy


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