Posted by Larry Hoover on February 25, 2007, at 13:08:02
In reply to Re: MAO-A elevated in major depression, posted by psychobot5000 on February 25, 2007, at 11:18:42
> Also, for all the focus on MAO-a, this type of data does not seem to accound for selegiline/Emsam's apparently greater efficacy than Moclobemide--which meta-analyses show is sligtly less effective than SSRIs. Practitioners in European countries have apparently been disappointed with it.
Moclobemide is alone in this category in being a reversible inhibitor. It's a competitive inhibitor (different Lineweaver-Burk plots), whereas the others do damage to the binding site of the enzyme.
Lar
poster:Larry Hoover
thread:734868
URL: http://www.dr-bob.org/babble/20070224/msgs/736038.html