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Re: MAO-A elevated in major depression }} Lar (nm)

Posted by sdb on February 23, 2007, at 13:08:23

In reply to Re: MAO-A elevated in major depression }} Lar » sdb, posted by Larry Hoover on February 23, 2007, at 8:04:54

> > > Pretty robust p values.....to 10 ^-7.
> > >
> > > http://archpsyc.ama-assn.org/cgi/content/abstract/63/11/1209
> > >
> > > Lar
> >
> > Interesting arcticle, is a robust p value if there's no bias and other things.
> >
> > sdb
>
> Here's why I think the small sample size is less relevant:
> 1. They sampled 10 brain regions, and every one was significantly different between the two groups. Not one exception.
> 2. The smallest chance estimate was p < .001.
> 3. If you consider each regional assay as an individual experiment, then the chance probability for the entire set is the product of each estimate.....i.e. vanishingly small chance of it being a fluke finding.
> 4. They published validation studies for their method before they conducted this sampling exercise.
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16079787
>
> I can't find anything comparable in the literature. If anybody knows of one, please point it out to me.
>
> Now, as a preliminary finding, it most certainly will draw further funding and research. That's all I hope for. Hypoxia also causes MAO elevation in other disorders, in other tissues. How that comes to pass is the real question. Monoamine disturbance is the result of some predicate process, methinks. That's where my curiosity lies.
>
> Lar
>
>

Hi Lar

You answered exactly to what I wanted to point out.

warm regards

sdb


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