Posted by Larry Hoover on February 23, 2007, at 8:11:58
In reply to Re: MAO-A elevated in major depression, posted by notfred on February 22, 2007, at 18:07:07
> So the logical recourse is a MAOI of MAO-A, if I understand this brief extract ? That would exclude Emsam but include nardil and parnate. It might suggest why some MAOI's are more effective AD's than other classes.
I don't think it's wise to exclude drugs with proven efficacy based on an hypothesis alone.
The proven efficacy of MAO inhibition is consistent with these findings, yes. But it is not explained by these findings.
Like any antidepressant class, MAO inhibitors take weeks to become effective, despite the fact that the enzyme inhibition is nearly instantaneous (literally, on contact). So, the MAO-mediated mechanism is secondary to something else. Something we don't yet grasp. MAOIs are still analogous to duct tape. They're "fixing" something that isn't really fixed at all.
Lar
poster:Larry Hoover
thread:734868
URL: http://www.dr-bob.org/babble/20070219/msgs/735321.html