Posted by yxibow on February 21, 2007, at 19:13:03
In reply to Re: why are benzodiazpines abused? like opiates... » yxibow, posted by Chairman_MAO on February 21, 2007, at 12:59:07
> No, it is _IMPOSSIBLE_ in virtue of its mechanism of action. The BZD receptor complex can only potentiate GABA-A activity so much; there is a ceiling effect. There's a joke in pharmacology that the only way to kill a rat with alprazolam is to bury it alive in it. Sure, there's always an LD50. The LD50 of alprazolam in rats is 331-2171mg/kg! How could someone ever consume that much? You'd have to give yourself a bolus! Sure, you can be comatose, but that doesn't imply dangerous respiratory depression. You will eventually be un-comatose with only a lack of pharmacological savvy to show for it.
>
> There was a politician years ago who tried to off himself with diazepam in the face of a scandal; it didn't work. I've met people who've downed hundreds of pills of clonazepam and survived without any issues except sleeping a very long time.
I'd still prefer not to give people ideas on here of ways to... anyhow. That's why I didn't go there. Comatose isn't exactly much better than respiratory depression. Not everyone comes out of a coma. I can see your point, but I'd like to keep people on here alive, even if its not due to saturation of the GABA receptor.
poster:yxibow
thread:734714
URL: http://www.dr-bob.org/babble/20070219/msgs/734925.html