Posted by rovers95 on December 13, 2006, at 21:19:30
In reply to Riluzole = glutamate release inhibitor, posted by SLS on December 9, 2006, at 14:04:24
> Hi.
>
> Riluzole did not help me at all, but...
>
>
> - Scott
>
>
> ------------------------------------------
>
>
> Biol Psychiatry. 2006 Dec 1;
> [Epub ahead of print]
>
> Preliminary Evidence of Riluzole Efficacy in Antidepressant-Treated Patients with Residual Depressive Symptoms.
>
> * Sanacora G,
> * Kendell SF,
> * Levin Y,
> * Simen AA,
> * Fenton LR,
> * Coric V,
> * Krystal JH.
>
> Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
>
> BACKGROUND: Excessive glutamatergic neurotransmission may contribute to the pathophysiology of major depressive disorder (MDD). Recent evidence suggests that riluzole and other agents that target glutamate neurotransmission may show antidepressant activity. METHODS: Ten patients with treatment-resistant depression had riluzole added to their ongoing medication regimen for 6 weeks, followed by an optional 6-week continuation phase. Depression and anxiety severity were assessed using the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS). Linear mixed models were used to test for a linear trend in HDRS and HARS scores across time with treatment. RESULTS: Subjects' HDRS and HARS scores declined significantly following the initiation of riluzole augmentation therapy. The effect of riluzole was significant at the end of the first week of treatment and persisted for the 12-week duration of the study. CONCLUSIONS: These data suggest that riluzole augmentation produces antidepressant and anxiolytic effects in patients with treatment-resistant depression.
What dosage did u try? Unable to find the dosage used in the above trial but am i right in thinking
50mg is the therapeutic dosage?!mark
poster:rovers95
thread:711898
URL: http://www.dr-bob.org/babble/20061212/msgs/713394.html