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Re: SLS - riluzole » rovers95

Posted by SLS on December 13, 2006, at 7:27:40

In reply to Re: SLS - riluzole, posted by rovers95 on December 12, 2006, at 22:36:40

> Do you know how its NMDA antagonistic properties compare with that of memantine?!

Riluzole inhibits the release of glutamate so that there is less available to stimulate receptors, including NMDA receptors. Memantine directly blocks NMDA receptors from being stimulated by glutamate. Which is better? I don't know. There is the possibility that there is some importance in reducing the stimulation of the other two types of glutamate receptors (AMPA and Kainate), in which case there might be an advantage to using riluzole.


- Scott

 

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URL: http://www.dr-bob.org/babble/20061212/msgs/713177.html