Posted by yxibow on November 18, 2006, at 23:33:19
In reply to Re: Dopamine - Do you care about those Agonists ? » Quintal, posted by erik98225 on November 18, 2006, at 13:23:05
> > Does anyone else find that dopamine agonists generally make them feel light and energetic while antagonists make them feel heavy and tired? I find the mood brightening effect of amisulpride (D2 agonist) more satisfying and substantial than that produced by the SSRIs.
> You couldn't have said it better; I fully agree with this. Taking Haldol or Seroquel was miserable -- in the case of Seroquel, I took one pill and about 10 minutes later I wished I was dead and flushed the rest of the Seroquel down the toilet. I REALLY don't tolerate the anticholinergic crap. (I am a smoker; not trying to quit right now because I'm recently quit the much more dangerous Alcohol. I've heard that nicotine is a PROCHOLINERGIC.)
Its not the nicotine so much, but the 100+ other things in tobacco and cancer... but at any rate...
Some psychiatrists have been musing about other possibilities for the new smoking cessation drug Chantix (varenicline), antagonizing a4b2 nicotinic acetylcholine receptors, as a possible antidepressant. This isn't clear as to whether it actually has any function, although it has been noted that some sufferers of schizophrenia who also smoke seem to do better in general (and with neuroleptics) than those who don't smoke. This isn't a cause celebre to start smoking, but it is worth scientific pursuit.