Posted by SLS on July 2, 2006, at 14:26:21
In reply to RESERPINE, posted by hgi698 on July 2, 2006, at 13:32:54
> Well i previously mentioned that i became hypomanic upon withdrawal of an ssri. (dopamine receptor upregulation due to ssri induced dopamine depletion?). So i know it's possible to do. I am assuming that reserpine would be a more reliable way of depleting dopamine and causing dopamine receptor upregulation. The wheels are in motion, and i am probably going to try it in the next couple weeks. Just one more question, reserpine induced depletion is temporary right? When the drug leaves your system you should go back to normal??
Reserpine acts to irreversibly damage presynaptic storage vesicles by binding to the transporter sites. Recovery of neurotransmission depends on the synthesis and translocation of new vesicles. There is thus some lag time between the discontinuation of the drug and the normalization of neurological function. I believe this occurs between 48-72 hours.
- Scott
poster:SLS
thread:663324
URL: http://www.dr-bob.org/babble/20060701/msgs/663569.html