Psycho-Babble Medication | about biological treatments | Framed
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Found the study on reserpine pre-treatment

Posted by hgi698 on July 9, 2006, at 10:23:05

In reply to Re: RESERPINE, posted by linkadge on July 5, 2006, at 17:07:08

Reserpine Pretreatment and Augmentation

The use of reserpine in TRD has been reviewed by Zohar et al. (119). This strategy has been hypothesized to induce changes in postsynaptic receptor sensitivity in response to a reserpine-induced depletion of brain monoamines. It should also be recalled that reserpine has modest antipsychotic potency, providing a second possible mechanism of action. Several poorly controlled early studies reported outcomes on the order of 70% to 90% in patients treated with repeated intramuscular injections of 5 to 10 mg of reserpine (see ref. 119). Given such dramatic findings, it is curious that reserpine strategies have received so little subsequent attention. Perhaps this is because two recent controlled clinical trials have failed to support the value of this approach for TRD patients (3, 83).




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