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Re: What diffrence is the [I] isomer in amphetamine

Posted by PsychoPharmaFiender on February 4, 2006, at 12:52:56

In reply to Re: What diffrence is the [I] isomer in amphetamine, posted by mike99 on February 4, 2006, at 12:18:42

What may not seem like alot on paper sometimes does not translate that way in terms of clinical effects on people. Lots of people respond better to adderall than Dexedrine, the only difference is that Adderall contains DL amphetamine, where as Dexedrine is D amphetamine.

Same thing for Celexa and Lexapro.

> Amphetamine is either in the form of an L or D isomer (levoamphetamine or dextroamphetamine).
>
> You're correct that the D isomer is more active in the brain whereas the L isomer has minimal effects on the brain compared to its peripheral actions on the body (heart rate, blood pressure).
>
> It may be a matter of debate, but I don't think the L-isomer is of much if any benefit in terms of stimulating the brain (ie having any clinical benefits-- it is active in the brain to a small degree).
>
>


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URL: http://www.dr-bob.org/babble/20060129/msgs/606284.html