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Re: Buprenorphine nasal spray!

Posted by reefer on January 7, 2006, at 17:04:19

In reply to Re: Buprenorphine nasal spray! reefer, posted by ed_uk on January 7, 2006, at 12:50:25

> I'm interested :) Keep us updated.
>
> Ed

Hi Ed! This article might be of interest:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11000552&dopt=Abstract

Do they mean 5% dextrose in a water solution? Another thing i've noticed when dissolving Subutex tablets in cold water is that some of it remains undissolved(fillers). And it is easy to filter most of that out by just sucking it(the solution) up through a ball of cotton. So i'm thinking, maybe first filtering out the crap and then adding Dextrose would be a good idea. Because i think i read in another article that the bioavailability of pure intranasal bupe hcl solution was 50% compared to i.v. Increasing that up to 80 - 90% by just adding dextrose would be excellent.

The other constituents of a Subutex SL tablet:
Lactosemonohydrate 191,8 mg, mannitol 120 mg, cornstarch, Povidone, waterfree ascorbic acid, sodiumcitrate, magnesiumstearate.


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poster:reefer thread:579345
URL: http://www.dr-bob.org/babble/20051231/msgs/596288.html