Posted by Larry Hoover on December 30, 2005, at 10:59:13
In reply to Re: Lamictal and Folic Acid - P-5-P and Neurontin » Larry Hoover, posted by Nickengland on December 29, 2005, at 8:43:04
> Hi Larry, (sorry to interrupt)
Sorry to read it and not twig on responding.
> I've been wondering about the interactions with B6 and anticonvulsants - more so Neurontin, with regards to how much B6 do you think is safe to take along side Neurontin (and other mood stabilisers in general) With the literature, is it best to keep B6 capped at a certain dosage and not any higher to prevent the interaction happening?We're all so different, it would be like me throwing statistics at you. Guideline intake is something like 2 mg/day. A normal healthy person needs at least that amount (really 7 times that amount a week, because they calculate RDA based on weekly intake), to avoid overt symptoms of deficiency. It's not clear what these mood stabilizers do, to affect B6. Is it enhanced excretion? Is it enhanced utilization? Is it bound up somehow? Blocked uptake?
So, if you're taking one of those B-complex formulations based on B-25 to B-50 range, you should be fine. The symptoms of B6 deficiency are vague, and poorly defined. They also would be mistaken for symptoms of a mood disorder, or side effects of a drug.
> Also, whats P-5-P like compared to pyridoxine hydrochloride - would it be possible you could take more of the P-5-P form and so get less of an interaction?
Believe it or not, in just checking some references for this reply, I found one source claiming that P-5-P cannot be taken up from the gut. This astounds my brain, so I'm going to have to defer answering this bit while I cogitate.
> Many thanks if you can answer this. I find great benefits from alot of the B-vitamins and B6 in particular, but also find that at some dosages it can stop the benefits I get from anticonvuvlsants so i'm looking for ways to get the best of both worlds..
>
> Best regards
>
>
> NickTell me about this "stopping the benefits" effect from B vitamins, and the dose you were taking.
Lar
poster:Larry Hoover
thread:589643
URL: http://www.dr-bob.org/babble/20051221/msgs/593409.html